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30 37 ... 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37
291 300 366

:

  1. #291
      bode
    Jun 2007
    2,818


    ѿ . . . .


    : . " " .

    . ɡ " " . . .

    600 .

    :

    : 75%. ".. " . ڡ 1944.

    25% 1944 1955. 1995 2004 76.5 . " ". .

    . . 1994 . 22%.


    .
    400

    400 . " " 5 /ѡ / .

    2004 500 " ". " . ". " ".

    300 . ʡ . . " ".

    " ˡ . ".

    . " ". " " .

    ˡ 60 . "" " 500 ɡ ".




    ( ) . 18 .

    . 418 .

    1,85 3,5 12 . 14 10 .

    .




    .

    ".." . ɡ (..) . .

    " 2020 70 ". .

    " 25 ... ". . 13.2 2030 2008 . 75 .

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    . . .

    . .

    50 50 . " . .. ".

    10 ..


    ǡ ȡ 100 ǡ ʺ .

    ɡ ǡ . .

    200 50 65 .

    *

    * 2003 2007 ɡ һ .

    *

    * (792495 ). . ڡ 55 65 ǡ . : ɡ ǡ ɡ . 157 2010.

    (268783 ). ̡ . ɡ . ɡ ߻ . 51 2010.

    *

    * (206983 ). ɡ ϡ ߻. 2000 2003 2008. . 40 2010 .

    (162878 ). ӡ . ǡ ǡ ߻. 37 2010 .

    (144926 ). . ɡ ǡ . ɡ ǡ ɡ ܫ ߻. 32 2010 .

    *

    * (108740 ). ɡ . Ǻ () ɡ 41714 2003 2007. 22 2010.

    (104407 ). ɡ . ɡ ɡ . ɡ 20 2010.

    (79773 ). ɡ ߻. . . ɡ . 19 2010 .

    (73638 ). 2003 2007 . 63 . . ա ߻. . 14 2010 .

    (66659 ). ( ) ߻. 2003 2007 . 14500 2010.

  2. #292
      bode
    Jun 2007
    2,818


    : . . " " " 110 ".


    " " - "" - . " " " ". .


    . 650 .

    " .. ǡ ".


    . . . ɡ Ի Hoffman La Roche ɡ ɡ 3 . Mammography . . ɡ ڡ ֡ ɡ . ɡ .

    ɡ 82,9 ɻ 40 . Ի ɡ .

    ɡ ɡ . .

    40 ɡ ɡ ɡ . ʡ 9 ʡ ɻ .




    "" 3000 ɡ 60 . " " ڡ .

    . 37 16 . 35 . .

    ɡ . . 3000 .

    ѡ :" ". ɡ " " .

    ǡ :" . ˡ ( 43 % ) . ".

  3. #293
      bode
    Jun 2007
    2,818

    Medical :

    :

    : . "" " " .

    . " 25% ".


    : . " " 650 . . 50 30 45 .

    ȡ 4 ѡ . 6 . " .. ǡ ".


    "" 25%.. ". .


    .

    ҡ ȡ ߡ 3 ѡ 4.6 .

    ޡ ɡ ɡ 3 . ɡ . .

    . . :" ɡ ".

    ɡ ϡ . ɡ ϡ ǡ . ȡ ȡ . . .

    ɡ ǡ . ǡ . . ϡ . " " . . .


    . .
    .

    1. 40 .
    2. (CBE) 40 - .
    3. CBE 20 39 .
    4. 20 .
    5. - 50 ۡ .
    6. : .
    7. phytoestrogen .
    8. .
    9. .

  4. #294
      bode
    Jun 2007
    2,818


    ɡ Histone deacetylases ((HDAC. (Virginia Commonwealth University Massey Cancer Center). . () . ߡ ɡ ɡ ǡ .

    ɡ "" (Nemo). ((HDAC ɡ . ǡ ɡ (NF-κB). ɡ ʡ . ߡ ((HDAC . "". ǡ (NF-κB). ȡ "" (NF-κB) . ((HDAC .


    :


    : . " " " " "" .

    " ". . " ".



    . . - .

    / . . .


    . (MetMAb) .

    . () .. .



    .. . - ( ) - . .

    70% () () . () .



    ֡ . (NCI) () (Cancer Vaccines) . ɡ .

    *

    * ɡ .

    * ((Leucocytes ( ) Lymphocytes)) : - B ( ): ɡ (Antibodies) .

    - T ( ): (T - Killer cells) ɡ ʡ ɻ (Apoptosis).

    - : (T - Helper cells) (Dendritic cells) B T ǡ T ɡ .

    * : (Self antigens) (Non - self Antigens) ǡ .. (Memory of immune system). .

    *

    * (Antigens) ǡ ֡ (Antibodies) .

    :

    - (Preventive cancer vaccines) .
    - (Treatment cancer vaccines) .

    15 25 . ɡ ɡ (IARC) :

    * :

    - (B) Hepatocellular carcinoma)).

    - (C) ( B). - (HPV) ( 16 18) 70 17 30 (Cancer cervix).

    - (HPV) ( 16 18) (Vaginal cancer) Vulvular cancer)) Cancer penis)) (Oropharyngeal cancers).

    - ( 6 11) 90 (Genital warts) .

    - (EBV) (Lymphomas) (Burkitt lymphoma) (Nasopharyngeal cancer).

    - (HTLV) () T (T - cell leukemia).

    * : (Helicobacter pylori) .

    * :

    - (S. Hematobium) .
    - (Opisthorchis viverrini) .

    *

    * . ɡ .

    * (B) (HBsAg) (HPV) . ɡ .

    * (Synthetic antigens) (Modified antigens) .

    *

    * (FDA) :

    * (HBV) FDA 1981 .

    * (B) (HBV - DNA modified) ɡ ( ɡ ѡ 6 ѡ 5 ).

    * HPV:

    - Gardasil: (6 11) (16 18).. ɡ . (16 18) (Genital warts) (6 11). 9 26 .

    Cervarix: (16 18) .. ء . 10 26 (16 18).

    *

    * B T ɡ . (Antigens) :

    - .
    - .
    - ɡ ( ) ( ).
    - (DNA) (RNA) .

    :

    - .
    - .
    - .
    - .

    ʡ :

    - .

    - : ( (Cancer associated antigens) ɡ T .

    - (Adjuvant molecules) BCG (). - .

    - .


    * FDA () 2010 (Provenge) (Metastatic cancer prostate) . ѡ . Provenge .. ֡ (PAP) ǡ ɡ (PAP). ɡ . 93 .

    ˡ (Solid tumors).

    *

    * ɡ .

    :

    - .
    - .
    -

    *

    * . ͡ .

    :

    - .
    - ǡ ɡ ݡ ʡ .
    - .
    - ɡ ɡ ( ɡ ).
    - .

  5. #295
      bode
    Jun 2007
    2,818

    Medical


    . " " ( ) . ( ) . .

    " " . " ". . .



    : . "" " ". " ".

    " " " " " " . " ɡ 2% " .

    ""

    : "" . "" "" ϡ 27% . ˡ .

    "- 1" "" . "- 1" . "" "" " 2 " .



    .

    . ϡ ڡ . . .

    ѡ T-DM1 - 1 . ܫ ɻ ѻ . . . . .

    ӻ ɡ Ի . ҡ ɻ . : . - 1 .

    Tarceva ǻ . . Ի 4 12 .


    170 500 ޡ . ɡ 11 . !


    ϡ .

    ( ) ɡ .. ... 28 2002 10 .

    10

    .. ( ) 30 ǡ . (1989) .. .. 10 ޡ 14500 !.

    " ɡ () ɡ .


    4800 ɡ " 2004 " " " ". .. ". ɡ . ǡ 11 711 38 ǡ ݡ ѡ 17 ǡ .


    ɡ ˡ 1050 1000 ˡ 2005 18 ɡ 850 1000 ɡ ˡ .

    300

    300 . 300 .

    . 150 .

  6. #296
      bode
    Jun 2007
    2,818


    : . "" 51,928 12 1,268 43% . ݡ .

    :

    : . " " "" 85 .

    ɡ . " .. ".


    : . " " 13 39% . . .


    . . 43% 4 .

    . .. , .


    8 : 10 ޡ 40 % . ѡ 40 ޡ .

    75 . ڡ ǡ ѡ " " " " .

    ɡ . .

    ɡ .


    " " . ɡ ֡ . ɡ ݡ " " . ɡ : " ʡ ̡ .

    ɡ . ʡ . ɡ " " ѡ ".

    ɡ : ɡ ʡ .

    " ɡ ɡ ". " " ѡ : "


    50 . "" " " .

    " . .. ". .



    ɡ . - - ǡ . . .

    ǡ . . . 150 .

    ϡ ѡ . : . ɡ ǻ.

    ˡ . .

    ѡ . ǡ . .

    ݻ : . . ǻ.

    ء ӡ .




    . ޡ .

    50 ǡ . . :

    " " . " " 93% .

    . ɡ .


    .

    " "

    .


    ɡ ǡ .

    " "

    ޡ . .

    " 91% ". " " 1973 ʡ .
    :

  7. #297
      bode
    Jun 2007
    2,818



    .. .. 40.000 . ( ) - .

    - (maytansine) - () . .



    ǡ .

    ɡ . ( ) ϡ .

    ǡ . ( ) . ( ) .

    ɡ ǡ .

    ֡ . " " ɡ .



    : ǿ

    ǻ (PSA) ɡ ǻ . . ǡ ǡ .

    . ݡ . . ߡ PSA ɡ .

    *

    * PSA

    ǡ ɡ 60 . ۻ PSA ǡ . ߡ .

    1167 . ʡ 43 35 . PSA 2.0 ֡ 25 .

    1 4 PSA 2.0 ǡ ҡ ۻ. ѡ .

    . 2.0 26 ɡ 1.0.

    ڡ PSA 2.0 25 ɡ 6 ɡ 17 PSA 5. : ɡ ջ.

    PSA 1.0 25 ɡ ɡ 0.2 . : . ʻ.

    *

    * 1.0 2.0 . ǡ . 1 3 ɡ . PSA . .

    ɡ PSA 1.5 . : (PSA) .

    PSA ߡ . PSA . . 50 54 . 55 69 PSA ɡ .

    PSA 50 . 2008 21 仡 25 PSA 0.9 .

    . PSA . . : . .




    : 83 100

    . .

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    : .

    : .
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    83 100 . 27% 2007 40% 2010 .


    . . . .

    ѡ . . ڡ . : ɡ .

    ǡ 550 ɡ . . .

    : 70 . 36 . 44 .

    ǡ . :

    : 100 ϡ . . : ˡ . . ߡ ɡ . : . . .

    : .

    : ɡ . 50 ɡ . ɡ . ɡ . .

    2003 30 20 . 37 . .

    : .

    : . . . : .

    : .

    : ˡ 1964. 180 : . . 40 . .

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    . ۡ . 30 ǡ . ϡ .

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    ɡ . . . . ɡ ϡ . .


  8. #298

    Oct 2010
    31

    :

    .

  9. #299
      bode
    Jun 2007
    2,818


    (e) .. (tocotrienol T3) . 70% tocotrienol T3 .

    (tocotrienol T3) .. . : (e) .. .

    :

    : . ɡ .

    11 2002 . 12 ɡ 62 31. 24% 16% .

    .



    : . " " .

    " " . .


    12%. . - ѡ - .

    - - ʡ . 22 2.5 .

    12% . / .
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    ... 20


    . : ֡ 廡 ɡ . ʡ ڡ . 20 .

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    . . ߡ .

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    . . ϡ : . 55 . .

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    25 .

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    9-

    . . .

      10-

    . . . ɡ .

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    .

    69 .
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    20% 30% .

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    90 . . 0 ( ) 1 ( ) . ѡ . 2 ( ) 86 .

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    : . .

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    16-

    ( ) ɡ . .

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    50 . .

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    . 50 . . . .

    19-

    . .

    20-

    ( ) . .

    : . 1 % . ɡ 60 70 . . . ( ɡ ʡ ).

  10. #300
      bode
    Jun 2007
    2,818



    ɡ . ɡ ֡ .

    . ǡ . .


    . . 11 .

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    : 3 ɡ .

    2010 2012 ɡ . ǡ ȡ ǡ " ".

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    ɡ ɡ .

    "" 5 ɡ 25% ɡ . .



    . . . .

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    14 . 18 2.8 . 20 24 35 .
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    : ɡ 1993 " " . " () 15 ǡ ". " ɡ ".

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    " ". 15 ǡ 1993 2007.

    " 698 1993 2007 15 56 ". " 97 2006" " " .

    ϡ " ݡ " . ɡ . 1980-1988 1991 2003.

    - " ". 1991. ʡ 1991 2003. . ӡ .


    ɡ 8000 . .

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